The change that led to lens regeneration in babies was performing cataract surgery with wound opening that is much smaller and on the side, instead of on the front of the eye.Study Outcome

"The current capsulorhexis method performed in paediatric cataract surgery involves making a large 6-mm-diameter opening at the centre of the anterior capsule, resulting in a large wound area and destruction of large numbers of LECs (Extended Data Fig. 1c). To overcome these limitations and to facilitate lens regeneration, we established a new capsulorhexis method. This new method has two advantages: (1) it reduces the size of the wound considerably; and (2) it moves the cap- sulorhexis opening from the central visual axis to the periphery. Thus, application of this procedure led to improved visual axis transparency and preservation of LECs with regenerative potential (Fig. 3a)."

Haotian Lin, Hong Ouyang, Jie Zhu, Shan Huang, Zhenzhen Liu, Shuyi Chen, Guiqun Cao, Gen Li, Robert A. J. Signer, Yanxin Xu, Christopher Chung, Ying Zhang, Danni Lin, Sherrina Patel, Frances Wu, Huimin Cai, Jiayi Hou, Cindy Wen, Maryam Jafari, Xialin Liu, Lixia Luo, Jin Zhu, Austin Qiu, Rui Hou, Baoxin Chen in Lens regeneration using endogenous stem cells with gain of visual function Scientific Paper

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