BMI1 protein is needed for multiplication of LEC cells and lowering efficiency of this process promotes cataract formation.Study Outcome

"These data suggest that Bmi1 loss of function disrupted LEC proliferation, thereby depleting the LEC pool and promoting cataract formation."

Haotian Lin, Hong Ouyang, Jie Zhu, Shan Huang, Zhenzhen Liu, Shuyi Chen, Guiqun Cao, Gen Li, Robert A. J. Signer, Yanxin Xu, Christopher Chung, Ying Zhang, Danni Lin, Sherrina Patel, Frances Wu, Huimin Cai, Jiayi Hou, Cindy Wen, Maryam Jafari, Xialin Liu, Lixia Luo, Jin Zhu, Austin Qiu, Rui Hou, Baoxin Chen in Lens regeneration using endogenous stem cells with gain of visual function Scientific Paper

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